Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering contributes to pattern formation during morphogenesis. With a computational model we show that a system of elongated, cohering biological cells can get dynamically arrested in a network pattern. Our model provides a new explanation for the formation of cellular networks in culture systems that exclude intercellular interaction via chemotaxis or mechanical traction.
American Physical Society
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics
Reconstructing the interactions between cells and extracellular matrix during angiogenesis
Life Sciences and Health

Palm, M.M, & Merks, R.M.H. (2013). Vascular networks due to dynamically arrested crystalline ordering of elongated cells . Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 87(1).