Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering contributes to pattern formation during morphogenesis. With a computational model we show that a system of elongated, cohering biological cells can get dynamically arrested in a network pattern. Our model provides a new explanation for the formation of cellular networks in culture systems that exclude intercellular interaction via chemotaxis or mechanical traction.
Additional Metadata
THEME Life Sciences (theme 5), Energy (theme 4)
Publisher American Physical Society
Journal Physical Review E: Statistical, Nonlinear, and Soft Matter Physics
Project Reconstructing the interactions between cells and extracellular matrix during angiogenesis , Reconstructing the interactions between cells and extracellular matrix during angiogenesis
Citation
Palm, M.M, & Merks, R.M.H. (2012). Vascular networks due to dynamically arrested crystalline ordering of elongated cells . Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 87(1).