Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation. The review provides an introduction for biologists for starting simulation analysis using the CPM framework.

Blood vessel formation, Cellular Potts model, Cystogenesis, Tube morphogenesis
Development Growth and Differentiation
Centrum Wiskunde & Informatica, Amsterdam, The Netherlands

Hirashima, T, Rens, E.G, & Merks, R.M.H. (2017). Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis. Development Growth and Differentiation, 59(5), 329–339. doi:10.1111/dgd.12358