It has recently been conjectured that metabolic pathways with membrane-bound enzymes can give rise to concentration gradients in the cytosolic pathway components. We investigate this issue using a theoretical model for the Phosphoenolpyruvate-dependent Phosphotransferase system in {it E. coli/, for which accurate measurements of the kinetic parameters are available. We show that significant spatial gradients indeed exist, and we discuss the potential implications of this finding.

LIFE AND MEDICAL SCIENCES (acm J.3), Partial Differential Equations (acm G.1.8)
Biochemistry, molecular biology (msc 92C40), Boundary value problems for first-order elliptic systems (msc 35J56), Boundary value problems for second-order elliptic systems (msc 35J57), Boundary value problems for higher-order elliptic systems (msc 35J58), Models, numerical methods (msc 65C20), Explicit machine computation and programs (not the theory of computation or programming) (msc 92-04)
CWI
Modelling, Analysis and Simulation [MAS]
Computational Dynamics

Blom, J.G, & Peletier, M.A. (2000). Diffusive gradients in the PTS system. Modelling, Analysis and Simulation [MAS]. CWI.