It has recently been conjectured that metabolic pathways with membrane-bound enzymes can give rise to concentration gradients in the cytosolic pathway components. We investigate this issue using a theoretical model for the Phosphoenolpyruvate-dependent Phosphotransferase system in {it E. coli/, for which accurate measurements of the kinetic parameters are available. We show that significant spatial gradients indeed exist, and we discuss the potential implications of this finding.

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CWI
Modelling, Analysis and Simulation [MAS]
Computational Dynamics

Blom, J.G, & Peletier, M.A. (2000). Diffusive gradients in the PTS system. Modelling, Analysis and Simulation [MAS]. CWI.