2000
Diffusive gradients in the PTS system
Publication
Publication
It has recently been conjectured that metabolic pathways with membrane-bound enzymes can give rise to concentration gradients in the cytosolic pathway components. We investigate this issue using a theoretical model for the Phosphoenolpyruvate-dependent Phosphotransferase system in {it E. coli/, for which accurate measurements of the kinetic parameters are available. We show that significant spatial gradients indeed exist, and we discuss the potential implications of this finding.
| Additional Metadata | |
|---|---|
| LIFE AND MEDICAL SCIENCES (acm J.3), Partial Differential Equations (acm G.1.8) | |
| Biochemistry, molecular biology (msc 92C40), Boundary value problems for first-order elliptic systems (msc 35J56), Boundary value problems for second-order elliptic systems (msc 35J57), Boundary value problems for higher-order elliptic systems (msc 35J58), Models, numerical methods (msc 65C20), Explicit machine computation and programs (not the theory of computation or programming) (msc 92-04) | |
| CWI | |
| Modelling, Analysis and Simulation [MAS] | |
| Organisation | Computational Dynamics |
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Blom, J.G, & Peletier, M.A. (2000). Diffusive gradients in the PTS system. Modelling, Analysis and Simulation [MAS]. CWI.
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