It has recently been conjectured that metabolic pathways with membrane-bound enzymes can give rise to concentration gradients in the cytosolic pathway components. We investigate this issue using a theoretical model for the Phosphoenolpyruvate-dependent Phosphotransferase system in {it E. coli/, for which accurate measurements of the kinetic parameters are available. We show that significant spatial gradients indeed exist, and we discuss the potential implications of this finding.

, , , , ,
Modelling, Analysis and Simulation [MAS]
Computational Dynamics

Blom, J., & Peletier, M. (2000). Diffusive gradients in the PTS system. Modelling, Analysis and Simulation [MAS]. CWI.