In [1, 6, 7] we studied whether metabolic pathways with membrane-bound enzymes can give rise to significant concentration gradients in the cytosolic pathway components. We investigated this issue using a theoretical model for the phosphoenolpyruvate:glucose phosphotransferase system in E. coli, for which accurate measurements of the kinetic parameters are available. In this study we modeled an E. coli by a sphere. In reality E. coli is rod-like or rather cigar-shaped. In this paper we discuss the implementational aspects and the potential implications of a more realistic geometry.

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Modelling, Analysis and Simulation [MAS]
Computational Dynamics

Blom, J., & Peletier, M. (2002). The importance of being cigar-shaped. Modelling, Analysis and Simulation [MAS]. CWI.