We show that a large class of secant varieties is nondefective. In particular, we positively resolve most cases of the Baur-Draisma-de Graaf conjecture on Grassmannian secants in large dimensions. Our result improves the known bounds on nondefectivity for various other secant varieties, including Chow varieties, Segre-Veronese varieties and Gaussian moment varieties. We also give bounds for identifiability and the generic ranks.