A non-homogeneous alternating renewal process model for interval censoring

Previous approaches to modelling interval-censored data have often relied on assumptions of homogeneity in the sense that the censoring mechanism, the underlying distribution of occurrence times, or both, are assumed to be time-invariant. In this work, we introduce a model which allows for non-homogeneous behaviour in both cases. In particular, we outline a censoring mechanism based on a non-homogeneous alternating renewal process in which interval generation is assumed to be time-dependent, and we propose a Markov point process model for the underlying occurrence time distribution. We prove the existence of this process and derive the conditional distribution of the occurrence times given the intervals. We provide a framework within which the process can be accurately modelled, and subsequently compare our model to the homogeneous approach through a number of illustrative examples.

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techReport A non-homogeneous Semi-Markov model for interval censoring M.N.M. van Lieshout (Marie-Colette) and R.L. Markwitz (Robin)