20160301
A functional central limit theorem for a Markovmodulated infiniteserver queue
Publication
Publication
Methodology and Computing in Applied Probability , Volume 18  Issue 1 p. 153 168
We consider a model in which the production of new molecules in a chemical reaction network occurs in a seemingly stochastic fashion, and can be modeled as a Poisson process with a varying arrival rate: the rate is $\lambda_i$ when an external Markov process $J(\cdot)$ is in state $i$. It is assumed that molecules decay after an exponential time with mean $\mu^{1}$. The goal of this work is to analyze the distributional properties of the number of molecules in the system, under a specific timescaling. In this scaling, the background process is sped up by a factor $N^{\alpha}$, for some $\alpha>0$, whereas the arrival rates become $N\lambda_i$, for $N$ large. The main result of this paper is a functional central limit theorem ({\sc fclt}) for the number of molecules, in that the number of molecules, after centering and scaling, converges to an OrnsteinUhlenbeck process. An interesting dichotomy is observed: (i)~if $\alpha>1$ the background process jumps faster than the arrival process, and consequently the arrival process behaves essentially as a (homogeneous) Poisson process, so that the scaling in the {\sc fclt} is the usual $\sqrt{N}$, whereas (ii)~for $\alpha\leq1$ the background process is relatively slow, and the scaling in the {\sc fclt} is $N^{1\alpha/2}.$ In the latter regime, the parameters of the limiting OrnsteinUhlenbeck process contain the deviation matrix associated with the background process $J(\cdot)$.
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doi.org/10.1007/s1100901494058  
Methodology and Computing in Applied Probability  
Coarse grained stochastic methods for biochemical reactions  
Organisation  Life Sciences and Health 
Anderson, D.F, Blom, J.G, Mandjes, M.R.H, Thorsdottir, H, & deTurck, K.E.E.S. (2016). A functional central limit theorem for a Markovmodulated infiniteserver queue. Methodology and Computing in Applied Probability, 18(1), 153–168. doi:10.1007/s1100901494058
