Cell-Based Modeling

A cell-based model is a simulation model that predicts collective behavior of cell-clusters from the behavior and interactions of individual cells. The inputs to a cell-based model are cell behaviors as observed in experiments or deriving from single-cell models, including the cellular responses to cues from the microenvironment. The cell behaviors are encoded in a set of biologically plausible rules that the simulated cells will follow. The outputs of a cell-based model are the patterns and behaviors that follow indirectly from the cell behaviors and the cellular interactions. Cell-based models resemble agent-based models, but typically contain more biophysically detailed descriptions of the individual cells.