The ability to explore huge digital resources assembled in data warehouses, databases and files, at unprecedented speed, is becoming the driver of progress in science. However, existing database management systems (DBMS) are far from capable of meeting the scientists’ requirements. The Database Architectures group at CWI in Amsterdam cooperates with astronomers, seismologists and other domain experts to tackle this challenge by advancing all aspects of database technology. The group’s research results are disseminated via its open-source database system, MonetDB.