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Optimizing drug delivery using non-uniform magnetic fields: a numerical study

  • Conference paper
4th European Conference of the International Federation for Medical and Biological Engineering

Part of the book series: IFMBE Proceedings ((IFMBE,volume 22))

Abstract

A comprehensive computational model for simulating magnetic drug targeting was developed and extensively tested in a cylindrical geometry. The efficiency for particle capture in a specific magnetic field and geometry was shown to be dependent on a single dimensionless number. The effect of secondary flows, a non-Newtonian viscosity and oscillatory flows were quantified. Simulations under the demanding flow conditions of the left coronary artery were performed. Using the properties of present-day magnetic carriers and superconducting magnets, approximately one third of 4µm particles could be captured with an external field. These promising results could open up the way to a minimally invasive treatment of coronary atherosclerosis.

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Author information

Authors and Affiliations

  1. Multi-Scale Physics, Delft University of Technology, Delft, The Netherlands

    J. W. Haverkort & S. Kenjereš

  2. J.M. Burgerscentre for Fluid Dynamics, The Netherlands

    S. Kenjereš

Authors
  1. J. W. Haverkort
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  2. S. Kenjereš
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Corresponding author

Correspondence to J. W. Haverkort .

Editor information

Editors and Affiliations

  1. Biomechanics and Engineering Design Section, KULeuven, Celestijnenlaan 300c - bus 2419, 3001, Heverlee, Belgium

    Jos Vander Sloten

  2. Cardiovascular Mechanics and Biofluid Dynamics Research Unit, Ghent University, De Pintelaan 185, 9000, Gent, Belgium

    Pascal Verdonck

  3. Medical Informatics Department, Free University Brussels, Laarbeeklaan 103, 1090, Brussels, Belgium

    Marc Nyssen

  4. Institute for Biomedical Engineering and Informatics, Technical University of Ilmenau, P.O. Box 100565, 98639, Ilmenau, Germany

    Jens Haueisen

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© 2009 Springer-Verlag Berlin Heidelberg

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Haverkort, J.W., Kenjereš, S. (2009). Optimizing drug delivery using non-uniform magnetic fields: a numerical study. In: Vander Sloten, J., Verdonck, P., Nyssen, M., Haueisen, J. (eds) 4th European Conference of the International Federation for Medical and Biological Engineering. IFMBE Proceedings, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_629

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  • DOI: https://doi.org/10.1007/978-3-540-89208-3_629

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89207-6

  • Online ISBN: 978-3-540-89208-3

  • eBook Packages: EngineeringEngineering (R0)

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